• Categories

  • Most Popular Questions

  • Recently Viewed Questions

  • Recent Answers

    How To Make a Digita… on What does a frequency of 100 H…
    Daigrepont on Can an earthquake cause air tu…
    Benedict on How did God come into exi…
    joshua on How does the human body g…
    Ian on How did God come into exi…
  • Recent Questions

  • Blog Stats

    • 2,220,209 hits
  • Visitors since 11-3-08

    counter create hit
  • Terms and Conditions

  • Warning

    We are doing maintenance on this site, so some posts may disappear for a short time. Sorry. Normal service will soon be resumed...
  • Pages

  • March 2008
    M T W T F S S
    « Feb   Apr »
     12
    3456789
    10111213141516
    17181920212223
    24252627282930
    31  
  • Archives

  • Meta

What is the Clinical Medicine evidence base?

Regarding Clinical Medicine (and in particular Mental Health interventions): Increasingly we have been “encouraged” to place our faith in NICE guidelines and evidence based medicine, but we have had the recent news that the drugs don’t work. My question is: what is the evidence base for the evidence base.
Sam Gothard from Greater London (Age 35-44)

Advertisements

One Response

  1. All the drugs that are released into the global market have to undergo testing phases.
    They test numerous things including how the drug is absorbed into the body, excreted from the body and the appropriate dose required to provide the desired affect.
    The evidence base that you refer to is based on Statistics. These statistics say that in order for you to state that the drug is effective you have to show that the difference between the placebo (or current treatment) and your treatment is clinically relevant (worth the money to produce it).
    We then use statistical formula based on this clinically relevant difference, the power required (1- beta where beta is known as a Type II error), the significance level (known as a Type I error) and the expected variance between the subjects to calculate how many patients are need to show this result.
    We can then test our Null Hypothesis: that there is no difference between the treatments against the Alternative Hypothesis: that there is a clinically relevant difference between the treatments.
    As a note, a type I error is the probability of rejecting the null hypothesis when it is true, typically set to 5%. A type II error is the probability of failing to reject the null hypothesis when the alternative is true.

    We then conduct the test and if the difference between the treatments is significant then the drug is said to have evidence of its effectiveness. That is that it would be unusual to see the difference observed if the treatments had the same effect.

    In essence the evidence base is statistics.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: